Wednesday, July 23, 2014

Management of patients with HER2-positive metastatic breast cancer: Is there an optimal sequence of HER2-directed approaches?

Management of patients with HER2-positive metastatic breast cancer: Is there an optimal sequence of HER2-directed approaches?
Cancer

The successful development of therapies targeting the human epidermal growth factor receptor 2 (HER2) has altered the natural progression of disease among patients with HER2-positive metastatic breast cancer. The monoclonal antibody trastuzumab was the first HER2-directed agent and it was associated with significantly improved outcomes for patients. Subsequently, other HER2-directed agents such as the monoclonal antibody pertuzumab, the tyrosine kinase receptor inhibitor lapatinib, and the immunoconjugate trastuzumab emtansine were developed to overcome resistance to trastuzumab and provide additional treatment options for patients. Recent data have demonstrated that the use of these HER2-directed agents improves outcomes. However, with the emergence of new HER2-targeted agents, the optimal sequencing of treatment remains unclear. Ongoing research is investigating new HER2 combinations, the role of sequencing, novel HER2-directed agents, and combinations with other targeted agents to overcome resistance. Cancer 2014 © 2014 American Cancer Society.



Original Article: http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002/cncr.28815

Livro Impresso: Após um Tumor Cerebral

Livros apos um tumor cerebral - 15058212 (IDPROD_15058212-ISBN_9788564855915) - 58% de Economia - Buscapé



http://www.buscape.com.br/apos-um-tumor-cerebral-15058212-idprod-15058212-isbn-9788564855915.html#precos

WFNS - 15th Interim Meeting of the World Federation of Neurosurgical Societies - SEPTEMBER 8-12 | 2015

WFNS - 15th Interim Meeting of the World Federation of Neurosurgical Societies - SEPTEMBER 8-12 | 2015


http://www.wfnsinterimrome2015.org/

Why Science Is Important

Why Science Is Important
Scientific American: Mind and Brain

Our own track record proves that steady federal funding support leads to success

-- Read more on ScientificAmerican.com


Original Article: http://www.scientificamerican.com/article/why-science-is-important/

Monday, July 21, 2014

New research: teaching the brain to reduce pain

New research: teaching the brain to reduce pain
Neurology News & Neuroscience News from Medical News Today

People can be conditioned to feel less pain when they hear a neutral sound, new research from the University of Luxembourg has found.

Original Article: http://www.medicalnewstoday.com/releases/279502.php

Defining the clinical course of multiple sclerosis: The 2013 revisions

Defining the clinical course of multiple sclerosis: The 2013 revisions
Neurology current issue

Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on a survey of international MS experts provided purely clinical phenotypes based on data and consensus at that time, but imaging and biological correlates were lacking. Increased understanding of MS and its pathology, coupled with general concern that the original descriptors may not adequately reflect more recently identified clinical aspects of the disease, prompted a re-examination of MS disease phenotypes by the International Advisory Committee on Clinical Trials of MS. While imaging and biological markers that might provide objective criteria for separating clinical phenotypes are lacking, we propose refined descriptors that include consideration of disease activity (based on clinical relapse rate and imaging findings) and disease progression. Strategies for future research to better define phenotypes are also outlined.



Original Article: http://www.neurology.org/cgi/content/short/83/3/278?rss=1

[In Context] Does neurology need a faster FDA?

[In Context] Does neurology need a faster FDA?
The Lancet Neurology

The FDA's neurology division has been reported as the slowest of all the agency's divisions at approving new drugs. If this is true, the economic impact could be affecting drug innovation and ultimately patient care. But what, if anything, needs to be done? Adrian Burton investigates.

Original Article: http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70162-0/fulltext?rss=yes

The role of diffusion tensor imaging in brain tumor surgery: A review of the literature

The role of diffusion tensor imaging in brain tumor surgery: A review of the literature
Neurosurgery News

Clinical Neurology and Neurosurgery

Original Article: http://www.mdlinx.com/neurology/news-article.cfm/5362289/?xml

Researchers advocate for more scientific research on consciousness

Researchers advocate for more scientific research on consciousness
Neurology News & Neuroscience News from Medical News Today

Why does a relentless stream of subjective experiences normally fill your mind? Maybe that's just one of those mysteries that will always elude us.

Original Article: http://www.medicalnewstoday.com/releases/279498.php

Top Hospitals for Neurology and Neurosurgery

Top Hospitals for Neurology and Neurosurgery
Medscape NeurologyHeadlines

US News & World Report ranks the top 10 US neurology and neurosurgery hospitals.
Medscape Medical News

Original Article: http://www.medscape.com/viewarticle/828289?src=rss