Saturday, November 22, 2014

“Potential Therapy Found for Incurable Pediatric Brain Tumor,” Robert H. Lurie Comprehensive Cancer Center at Northwestern University

"Potential Therapy Found for Incurable Pediatric Brain Tumor," Robert H. Lurie Comprehensive Cancer Center at Northwestern University
National Comprehensive Cancer Network

Northwestern Medicine scientists have discovered a new potential drug therapy for a rare, incurable pediatric brain tumor by targeting a genetic mutation found in children with the cancer. By inhibiting the tumor-forming consequences of the mutation using an experimental drug called GSKJ4, they delayed tumor growth and prolonged survival in mice with pediatric brainstem glioma. Robert H. Lurie Comprehensive Cancer Center at Northwestern University is one of the 25 NCCN Member Institutions....

Original Article: http://www.feinberg.northwestern.edu/news/2014/11/Hashizume-pediatric-tumor-therapy.html

How Doctors Determine the Moment of Death [Excerpt]

How Doctors Determine the Moment of Death [Excerpt]
Scientific American: Mind and Brain

The definition of death is hazy but important for medical decisions, explains Harvard neurologist Allan Ropper in the new book Reaching Down the Rabbit Hole  

-- Read more on ScientificAmerican.com


Original Article: http://www.scientificamerican.com/article/how-doctors-determine-the-moment-of-death-excerpt/

Facial Nerve Preservation Surgery for Koos Grade 3 and 4 Vestibular Schwannomas

Facial Nerve Preservation Surgery for Koos Grade 3 and 4 Vestibular Schwannomas
Neurosurgery - Most Popular Articles

imageBACKGROUND: Facial nerve preservation surgery for large vestibular schwannomas is a novel strategy for maintaining normal nerve function by allowing residual tumor adherent to this nerve or root-entry zone. OBJECTIVE: To report, in a retrospective study, outcomes for large Koos grade 3 and 4 vestibular schwannomas. METHODS: After surgical treatment for vestibular schwannomas in 52 patients (2004-2013), outcomes included extent of resection, postoperative hearing, and facial nerve function. Extent of resection defined as gross total, near total, or subtotal were 7 (39%), 3 (17%), and 8 (44%) in 18 patients after retrosigmoid approaches, respectively, and 10 (29.5%), 9 (26.5%), and 15 (44%) for 34 patients after translabyrinthine approaches, respectively. RESULTS: Hearing was preserved in 1 (20%) of 5 gross total, 0 of 2 near-total, and 1 (33%) of 3 subtotal resections. Good long-term facial nerve function (House-Brackmann grades of I and II) was achieved in 16 of 17 gross total (94%), 11 of 12 near-total (92%), and 21 of 23 subtotal (91%) resections. Long-term tumor control was 100% for gross total, 92% for near-total, and 83% for subtotal resections. Postoperative radiation therapy was delivered to 9 subtotal resection patients and 1 near-total resection patient. Follow-up averaged 33 months. CONCLUSION: Our findings support facial nerve preservation surgery in becoming the new standard for acoustic neuroma treatment. Maximizing resection and close postoperative radiographic follow-up enable early identification of tumors that will progress to radiosurgical treatment. This sequential approach can lead to combined optimal facial nerve function and effective tumor control rates. ABBREVIATIONS: GTR, gross total resection NTR, near-total resection STR, subtotal resection

Original Article: http://journals.lww.com/neurosurgery/Fulltext/2014/12000/Facial_Nerve_Preservation_Surgery_for_Koos_Grade_3.17.aspx

Thursday, November 20, 2014

Neurosurgery Internet TV Show Friday 5 pm EST

Greetings

Here is the promo video for the 2nd weekly "Neurosurgery Internet TV" show

with George Mendes MD, Brazilian Neurosurgeon, who is currently in France doing a Senior Clinical Fellowship at Dupuytren University Hospital.


George is going to speak about Hybrid vascular neurosurgery- dual training open and endovascular methods

There will be a panel including Julio Pereira MD, Neurosurgeon from Sao Paulo, who will be moderator.

You can watch at


can tweet, comments, and questions, LIVE, at 5 pm EST Friday.

And if anyone has an idea for a presentation, we welcome ideas, etc.

John Bennett MD
for Julio Pereira MD

Wednesday, November 19, 2014

Bullets and Brain - Andrew Wilner MD Neurologist talks about his book

Bullets and Brain - Andrew Wilner MD Neurologist talks about his book

Check out this video on YouTube:

http://youtu.be/gHhzbwWCmJk

Neurosurgery App (FREE)

Neurosurgery App (FREE)

https://itunes.apple.com/br/app/neurosurgery-app/id587505622?l=en&mt=8


https://play.google.com/store/apps/details?id=com.sodavirtual.neurosurgery  

 

DESCRIPTION

Latest news, researches and blog about Neurology, Neuroscience and Neurosurgery.
To provide neurosurgeons with the most timely comprehensive and relevant clinical information to improve patient care.
The mission of Neurosurgery blog is to facilitate the equitable, global dissemination of high-quality health research; to promote international dialogue and collaboration on health issues; to improve clinical practice; and to expand and deepen the understanding of health and health care.

http://www.neurosurgic.com/index.php?option=com_myblog&show=neurosurgery-app-free-.html&Itemid=337

Why do we need to have so many meetings?

Why do we need to have so many meetings?
Scientific American: Mind and Brain

These days my calendar is a source of stress. My morning routine of reviewing my appointments for the day during my commute often leaves me dreading the coming workday—and frantically looking...

-- Read more on ScientificAmerican.com


Original Article: http://www.scientificamerican.com/blog/post/why-do-we-need-to-have-so-many-meetings/

Evaluation of permanent alopecia in pediatric medulloblastoma patients treated with proton radiation

Evaluation of permanent alopecia in pediatric medulloblastoma patients treated with proton radiation
Radiation Oncology

Background: To precisely calculate skin dose and thus to evaluate the relationship between the skin dose and permanent alopecia for pediatric medulloblastoma patients treated with proton beams. Methods: The dosimetry and alopecia outcomes of 12 children with medulloblastoma (ages 4-15 years) comprise the study cohort. Permanent alopecia was assessed and graded after completion of the entire therapy. Skin threshold doses of permanent alopecia were calculated based on the skin dose from the craniospinal irradiation (CSI) plan using the concept of generalized equivalent uniform dose (gEUD) and accounting for chemotherapy intensity. Monte Carlo simulations were employed to accurately assess uncertainties due to beam range prediction and secondary particles. Results: Increasing the dose of the CSI field or the dose given by the boost field to the posterior fossa increased total skin dose delivered in that region. It was found that permanent alopecia could be correlated with CSI dose with a threshold of about 21?Gy (relative biological effectiveness, RBE) with high dose chemotherapy and 30?Gy(RBE) with conventional chemotherapy. Conclusions: Our results based on 12 patients provide a relationship between the skin dose and permanent alopecia for pediatric medulloblastoma patients treated with protons. The alopecia risk as assessed with gEUD could be predicted based on the treatment plan information.

Original Article: http://www.ro-journal.com/content/9/1/220

Monday, November 17, 2014

Long-Term Cell Phone Use Linked to Brain Tumor Risk

Long-Term Cell Phone Use Linked to Brain Tumor Risk
Medscape NeurologyHeadlines

The most recent study results show that the risk for glioma triples with long-term exposure to radiofrequency electromagnetic fields emitted by wireless phones.
Medscape Medical News

Original Article: http://www.medscape.com/viewarticle/834888?src=rss

The Impact of Adjuvant Radiation Therapy for High-Grade Gliomas by Histology in the United States Population

The Impact of Adjuvant Radiation Therapy for High-Grade Gliomas by Histology in the United States Population
Neurosurgery Blog

The Impact of Adjuvant Radiation Therapy for High-Grade Gliomas by Histology in the United States Population
International Journal of Radiation Oncology * Biology * Physics

To compare the survival impact of adjuvant external beam radiation therapy (RT) for malignant gliomas of glioblastoma (GBM), anaplastic astrocytoma (AA), anaplastic oligodendroglioma (AO), and mixed anaplastic oligoastrocytoma (AOA) histology.

Original Article: http://www.redjournal.org/article/S0360-3016(14)03558-5/abstract?rss=yes

The post The Impact of Adjuvant Radiation Therapy for High-Grade Gliomas by Histology in the United States Population appeared first on NEUROSURGERY BLOG.



Original Article: http://neurocirurgiabr.com/the-impact-of-adjuvant-radiation-therapy-for-high-grade-gliomas-by-histology-in-the-united-states-population/?utm_source=rss&utm_medium=rss&utm_campaign=the-impact-of-adjuvant-radiation-therapy-for-high-grade-gliomas-by-histology-in-the-united-states-population